Animal Models in Translational Research: Rosetta Stone or Stumbling Block?

A review written by Bolker JA in Bioessays, 20 October 2017.

Leading animal models are powerful tools for translational research, but they also present obstacles. Poorly conducted preclinical research in animals is a common cause of translational failure, but even when such research is well-designed and carefully executed, challenges remain. In particular, dominant models may bias research directions, elide essential aspects of human disease, omit important context, or subtly shift research targets.

Read More